Adenovirus with DNA Packaging Gene Mutations Increased Virus Release
نویسندگان
چکیده
منابع مشابه
Adenovirus with DNA Packaging Gene Mutations Increased Virus Release
Adenoviruses (Ads) have been extensively manipulated for the development of cancer selective replication, leading to cancer cell death or oncolysis. Clinical studies using E1-modified oncolytic Ads have shown that this therapeutic platform was safe, but with limited efficacy, indicating the necessity of targeting other viral genes for manipulation. To improve the therapeutic efficacy of oncolyt...
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Adenoviruses (AdVs) are icosahedral viruses with double-stranded DNA (dsDNA) genomes. Genome packaging in AdV is thought to be similar to that seen in dsDNA containing icosahedral bacteriophages and herpesviruses. Specific recognition of the AdV genome is mediated by a packaging domain located close to the left end of the viral genome and is mediated by the viral packaging machinery. Our unders...
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ژورنال
عنوان ژورنال: Viruses
سال: 2016
ISSN: 1999-4915
DOI: 10.3390/v8120333